DegronMD

Uniprot ID: Q8IZT8

Source protein: Heparan sulfate glucosamine 3-O-sulfotransferase 5

Source gene: HS3ST5

Class: LIG_APCC_ABBAyCdc20_2

Location: 309:315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6763

ASA_SCORE: 93.1143

COIL: 0.9219

CONS_SCORE: 0.5783

DSS_SCORE: 0.1459

HELIX: 0.018

FCONS_SCORE: 1.2573

RIG_SCORE: 0.7482

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K309T	TCGA-B5-A3FA	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7306
p.K309T	DO52402	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7306
p.R311C	SIDM02059	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.719
p.R311H	TCGA-86-8075	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	TCGA-AP-A1DV	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO224573	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO1006	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO25386	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO43186	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	SIDM01962	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.I312T	TCGA-B5-A11E	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7078
p.I312T	DO41644	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7078
p.P314L	TCGA-FR-A3YO	SKCM	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P314L	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P314L	DO37419	SKCM	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.R311S	TCGA-69-7980	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	DO23678	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	ACH-001363	Lung Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	NCI-H2135	lung	COSMIC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.P314S	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.S308I	TCGA-86-8358	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S308I	DO25471	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K303R	TCGA-18-3409	LUSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K303R	DO26444	LUSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778

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Drug responses associated with HS3ST5 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KGRIHPE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT8	Heparan sulfate glucosamine 3-O-sulfotransferase 5	LIG_APCC_ABBAyCdc20_2	309:315	KGRIHPE	APC,CDC20,FZR1	0.6763	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KGRIHPE

Degron related mutations and impact score

Drug responses associated with HS3ST5 mutations

All proteins holding degron of KGRIHPE