DegronMD

Uniprot ID: Q8IZT8

Source protein: Heparan sulfate glucosamine 3-O-sulfotransferase 5

Source gene: HS3ST5

Class: LIG_APCC_ABBAyCdc20_2

Location: 309:315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6763

ASA_SCORE: 93.1143

COIL: 0.9219

CONS_SCORE: 0.5783

DSS_SCORE: 0.1459

HELIX: 0.018

FCONS_SCORE: 1.2573

RIG_SCORE: 0.7482

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K303R	TCGA-18-3409	LUSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K303R	DO26444	LUSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R325H	TCGA-44-3398	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325H	DO25030	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325H	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325H	ACH-000553	Lung Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R311S	TCGA-69-7980	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	DO23678	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	ACH-001363	Lung Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R311S	NCI-H2135	lung	COSMIC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6316
p.P318R	TCGA-77-8148	LUSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.P318R	DO26458	LUSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.R311H	TCGA-86-8075	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	TCGA-AP-A1DV	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO224573	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO1006	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO25386	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	DO43186	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.R311H	SIDM01962	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7133
p.S308I	TCGA-86-8358	LUAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S308I	DO25471	LUAD	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K303T	TCGA-AA-A010	COAD	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R325C	TCGA-AP-A056	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-AP-A0LM	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-AP-A1DV	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-EI-6917	READ	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-G3-AAV2	LIHC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-GM-A2DB	BRCA	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-H7-7774	HNSC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-L5-A88V	ESCA	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	TCGA-MA-AA43	CESC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO5179	BRCA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO219725	CESC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO14182	HNSC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO52296	LIHC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO36881	READ	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO43306	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO43186	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	DO43971	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	SIDM00083	Glioblastoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	ACH-000273	Brain Cancer	CCLE	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.R325C	SF539	central_nervous_system	COSMIC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I312T	TCGA-B5-A11E	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7078
p.I312T	DO41644	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7078
p.K309T	TCGA-B5-A3FA	UCEC	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7306
p.K309T	DO52402	UCEC	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.7306
p.P314L	TCGA-FR-A3YO	SKCM	TCGA	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P314L	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P314L	DO37419	SKCM	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.6471
p.T322N	DO228974	LICA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D317E	DO229006	LICA	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P314S	DO229177	LMS	ICGC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.5641
p.R311C	SIDM02059	Colorectal Carcinoma	GDSC	KGRIHPE	LIG_APCC_ABBAyCdc20_2	0.719

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KGRIHPE

Degron related mutations and impact score

Drug responses associated with HS3ST5 mutations

All proteins holding degron of KGRIHPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZT8	Heparan sulfate glucosamine 3-O-sulfotransferase 5	LIG_APCC_ABBAyCdc20_2	309:315	KGRIHPE	APC,CDC20,FZR1	0.6763	More...