KIRREL3
UniProt ID: Q8IZU9
Entrez ID: 84623
Protein name: Kin of IRRE-like protein 3 (Kin of irregular chiasm-like protein 3) (Nephrin-like protein 2) [Cleaved into: Processed kin of IRRE-like protein 3]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. P...
FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250|UniProtKB:Q8BR86}.
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GO - Biological processes (BP):
cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron pro...
cell-cell adhesion [GO:0098609]; glomerulus morphogenesis [GO:0072102]; hemopoiesis [GO:0030097]; hippocampus development [GO:0021766]; homophilic cell adhesion via plasma membrane adhesion molecules [GO:0007156]; inter-male aggressive behavior [GO:0002121]; neuron migration [GO:0001764]; neuron projection morphogenesis [GO:0048812]; principal sensory nucleus of trigeminal nerve development [GO:0021740]; synapse assembly [GO:0007416]
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GO - Molecular function (MF):
cell adhesion molecule binding [GO:0050839]...
cell adhesion molecule binding [GO:0050839]
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GO - Cellular component (CC):
axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]...
axon [GO:0030424]; cell-cell junction [GO:0005911]; dendrite [GO:0030425]; dendritic shaft [GO:0043198]; extracellular region [GO:0005576]; integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]; synaptic vesicle [GO:0008021]
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KIRREL3
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Kaplan plot for KIRREL3 in
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*NOTE: the Kaplan plots were collected from OncoLnc