DegronMD

Uniprot ID: Q8IZU9

Source protein: Kin of IRRE-like protein 3

Source gene: KIRREL3

Class: DEG_APCC_KENBOX_2

Location: 455:459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6183

ASA_SCORE: 94.96

COIL: 0.44

CONS_SCORE: 0.4666

DSS_SCORE: 0.4152

HELIX: 0.0018

FCONS_SCORE: 0.8293

RIG_SCORE: 0.843

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E461D	TCGA-24-2290	OV	TCGA	WKENV	DEG_APCC_KENBOX_2	0.2778
p.E461D	DO30090	OV	ICGC	WKENV	DEG_APCC_KENBOX_2	0.2778
p.R467C	DO50316	ESAD	ICGC	WKENV	DEG_APCC_KENBOX_2	0.1111
p.T469M	DO233254	GACA	ICGC	WKENV	DEG_APCC_KENBOX_2	0.0556
p.S462L	DO220878	MELA	ICGC	WKENV	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZU9	Kin of IRRE-like protein 3	DEG_APCC_KENBOX_2	455:459	WKENV	APC,CDC20,FZR1	0.6183	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons