DegronMD - Q8N0S6(CENPL)

GO - Biological processes (BP): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S3F	TCGA-D8-A1JA	BRCA	TCGA	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation blocking phosphorylation signal	0.6667
p.S3F	DO2819	BRCA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation blocking phosphorylation signal	0.6667
p.G23S	TCGA-DU-6392	LGG	TCGA	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.0833
p.G23S	DO22237	LGG	ICGC	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.0833
p.D2N	TCGA-VQ-A8P2	STAD	TCGA	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation substituting flanking lysine	0.3056
p.D2N	DO51761	STAD	ICGC	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation substituting flanking lysine	0.3056
p.I22M	DO228546	LICA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation rewiring degron network	0.1111
p.A13E	DO229041	LICA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	7:14	Mutation altering degron motif	0.659

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons