DegronMD

Uniprot ID: Q8N0S6

Source protein: Centromere protein L

Source gene: CENPL

Class: DEG_SCF_FBW7_1

Location: 7:14

E3 ligase: FBXW7

DEGRON score: 0.9578

ASA_SCORE: 86.1

COIL: 0.913

CONS_SCORE: 0.3477

DSS_SCORE: 0.6645

HELIX: 0.0529

FCONS_SCORE: 1.0014

RIG_SCORE: 0.5686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3F	TCGA-D8-A1JA	BRCA	TCGA	PESTPSAS	DEG_SCF_FBW7_1	0.6667
p.S3F	DO2819	BRCA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	0.6667
p.G23S	TCGA-DU-6392	LGG	TCGA	PESTPSAS	DEG_SCF_FBW7_1	0.0833
p.G23S	DO22237	LGG	ICGC	PESTPSAS	DEG_SCF_FBW7_1	0.0833
p.D2N	TCGA-VQ-A8P2	STAD	TCGA	PESTPSAS	DEG_SCF_FBW7_1	0.3056
p.D2N	DO51761	STAD	ICGC	PESTPSAS	DEG_SCF_FBW7_1	0.3056
p.I22M	DO228546	LICA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	0.1111
p.A13E	DO229041	LICA	ICGC	PESTPSAS	DEG_SCF_FBW7_1	0.659

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0S6	Centromere protein L	DEG_SCF_FBW7_1	7:14	PESTPSAS	FBXW7	0.9578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons