DegronMD - Q8N0W5(IQCK)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T20A	TCGA-G6-A8L7	KIRC	TCGA	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.7139
p.T20A	DO50650	KIRC	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.7139
p.S22L	TCGA-NC-A5HO	LUSC	TCGA	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.8778
p.S22L	DO219197	LUSC	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.8778
p.T25S	DO50858	LICA	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.6005
p.V29A	DO229250	THCA	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	20:32	Mutation altering degron motif	0.6936

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons