DegronMD

Uniprot ID: Q8N0W5

Source protein: IQ domain-containing protein K

Source gene: IQCK

Class: DEG_COP1_1

Location: 20:32

E3 ligase: COP1

DEGRON score: 0.9808

ASA_SCORE: 84.2769

COIL: 0.8557

CONS_SCORE: 0.3034

DSS_SCORE: 0.4425

HELIX: 0.0643

FCONS_SCORE: 1.0664

RIG_SCORE: 0.7079

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T20A	TCGA-G6-A8L7	KIRC	TCGA	TDSSFTRTPVPTV	DEG_COP1_1	0.7139
p.T20A	DO50650	KIRC	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	0.7139
p.S22L	TCGA-NC-A5HO	LUSC	TCGA	TDSSFTRTPVPTV	DEG_COP1_1	0.8778
p.S22L	DO219197	LUSC	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	0.8778
p.T25S	DO50858	LICA	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	0.6005
p.V29A	DO229250	THCA	ICGC	TDSSFTRTPVPTV	DEG_COP1_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N0W5	IQ domain-containing protein K	DEG_COP1_1	20:32	TDSSFTRTPVPTV	COP1	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons