DegronMD - Q8N126(CADM3)

CADM3

UniProt ID: Q8N126

Entrez ID: 57863

Protein name: Cell adhesion molecule 3 (Brain immunoglobulin receptor) (Immunoglobulin superfamily member 4B) (IgSF4B) (Nectin-like protein 1) (NECL-1) (Synaptic cell adhesion molecule 3) (SynCAM3) (TSLC1-like protein 1) (TSLL1)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S256F	TCGA-3N-A9WC	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	TCGA-D3-A8GM	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	TCGA-EE-A20C	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	DO222542	MELA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	DO222775	MELA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	DO50288	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	DO47665	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.S256F	DO51234	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.R255T	TCGA-55-1596	LUAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7876
p.E248Q	TCGA-66-2786	LUSC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.R260C	TCGA-97-8174	LUAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1944
p.G252E	TCGA-AA-3713	COAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7199
p.G252E	TCGA-BF-A3DL	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7199
p.E262A	TCGA-AG-A002	READ	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1389
p.S240N	TCGA-AP-A059	UCEC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0833
p.R255I	TCGA-AX-A06F	UCEC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.8102
p.V263I	TCGA-EE-A180	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.R255K	TCGA-EE-A3AH	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7237
p.A239V	TCGA-EW-A1PG	BRCA	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0556
p.P239S	DO5326	BRCA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0556
p.P239S	DO42480	UCEC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0556
p.P239S	SNU-175	large intestine	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0556
p.P241H	DO8264	COAD	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.Q248R	DO233807	GACA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.3056
p.Q264H	DO25995	LUAD	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.0833
p.L251F	DO230931	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.587
p.L251F	DO224548	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.587
p.R257S	DO26446	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778
p.P260S	DO45482	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1944
p.R245C	DO27208	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2222
p.R245C	DO37474	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2222
p.H243N	DO47284	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1667
p.G247D	DO41871	UCEC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778
p.V263F	SIDM00683	Prostate Carcinoma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.V263F	ACH-000977	lymph node	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.V263F	LNCaP-Clone-FGC	prostate	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1111
p.C243F	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1667
p.D254H	SIDM01050	Biliary Tract Carcinoma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7688
p.D254H	ACH-001494	Bile Duct Cancer	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7688
p.D254H	EGI-1	biliary tract	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation altering degron motif	0.7688
p.V242M	SIDM01442	Glioma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1389
p.V242M	ACH-000807	Brain Cancer	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.1389
p.R257L	NCI-H2135	lung	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	249:255	Mutation rewiring degron network	0.2778

Kaplan plot for CADM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc