DegronMD

Uniprot ID: Q8N126

Source protein: Cell adhesion molecule 3

Source gene: CADM3

Class: LIG_APCC_ABBAyCdc20_2

Location: 249:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8527

ASA_SCORE: 46.3857

COIL: 0.0894

CONS_SCORE: 0.5053

DSS_SCORE: 0.6087

HELIX: 0.0011

FCONS_SCORE: 1.0625

RIG_SCORE: 0.7493

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S256F	TCGA-3N-A9WC	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	TCGA-D3-A8GM	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	TCGA-EE-A20C	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	DO222542	MELA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	DO222775	MELA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	DO50288	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	DO47665	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.S256F	DO51234	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R255T	TCGA-55-1596	LUAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7876
p.E248Q	TCGA-66-2786	LUSC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R260C	TCGA-97-8174	LUAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G252E	TCGA-AA-3713	COAD	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7199
p.G252E	TCGA-BF-A3DL	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E262A	TCGA-AG-A002	READ	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S240N	TCGA-AP-A059	UCEC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R255I	TCGA-AX-A06F	UCEC	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.8102
p.V263I	TCGA-EE-A180	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R255K	TCGA-EE-A3AH	SKCM	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7237
p.A239V	TCGA-EW-A1PG	BRCA	TCGA	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P239S	DO5326	BRCA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P239S	DO42480	UCEC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P239S	SNU-175	large_intestine	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P241H	DO8264	COAD	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q248R	DO233807	GACA	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Q264H	DO25995	LUAD	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.0833
p.L251F	DO230931	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.587
p.L251F	DO224548	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.587
p.R257S	DO26446	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P260S	DO45482	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R245C	DO27208	LUSC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.R245C	DO37474	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.2222
p.H243N	DO47284	SKCM	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G247D	DO41871	UCEC	ICGC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V263F	SIDM00683	Prostate Carcinoma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V263F	ACH-000977	lymph_node	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.V263F	LNCaP-Clone-FGC	prostate	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1111
p.C243F	SIDM01263	T-Lymphoblastic Leukemia	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D254H	SIDM01050	Biliary Tract Carcinoma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7688
p.D254H	ACH-001494	Bile Duct Cancer	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7688
p.D254H	EGI-1	biliary_tract	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.7688
p.V242M	SIDM01442	Glioma	GDSC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.V242M	ACH-000807	Brain Cancer	CCLE	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R257L	NCI-H2135	lung	COSMIC	KLLLHCE	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KLLLHCE

Degron related mutations and impact score

Drug responses associated with CADM3 mutations

All proteins holding degron of KLLLHCE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N126	Cell adhesion molecule 3	LIG_APCC_ABBAyCdc20_2	249:255	KLLLHCE	APC,CDC20,FZR1	0.8527	More...