NAGS
UniProt ID: Q8N159
Entrez ID: 162417
Protein name: N-acetylglutamate synthase, mitochondrial (EC 2.3.1.1) (Amino-acid acetyltransferase) [Cleaved into: N-acetylglutamate synthase long form; N-acetylglutamate synthase short form; N-acetylglutamate synthase conserved domain form]
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. {ECO:0000269|PubMed:12459178, ECO:0000269|PubMed:23894642, ECO:0000269|PubMed:7126172}....
FUNCTION: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPS1) activity. {ECO:0000269|PubMed:12459178, ECO:0000269|PubMed:23894642, ECO:0000269|PubMed:7126172}.
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GO - Biological processes (BP):
arginine biosynthetic process [GO:0006526]; glutamate metabolic process [GO:0006536]; urea cycle [GO:0000050]...
arginine biosynthetic process [GO:0006526]; glutamate metabolic process [GO:0006536]; urea cycle [GO:0000050]
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GO - Molecular function (MF):
acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; arginine binding [GO:0034618]; methione N-acyltransferase activity [GO:0103045]...
acetyl-CoA:L-glutamate N-acetyltransferase activity [GO:0004042]; arginine binding [GO:0034618]; methione N-acyltransferase activity [GO:0103045]
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GO - Cellular component (CC):
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]...
mitochondrial matrix [GO:0005759]; mitochondrion [GO:0005739]
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NAGS
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*NOTE: the Kaplan plots were collected from OncoLnc