DegronMD

Uniprot ID: Q8N159

Source protein: N-acetylglutamate synthase, mitochondrial

Source gene: NAGS

Class: DEG_COP1_1

Location: 76:84

E3 ligase: COP1

DEGRON score: 0.8778

ASA_SCORE: 97.5778

COIL: 0.9433

CONS_SCORE: 0.2755

DSS_SCORE: 0.6994

HELIX: 0.0252

FCONS_SCORE: 0.9407

RIG_SCORE: 0.565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W80L	DO228985	LICA	ICGC	EEPSWVPSP	DEG_COP1_1	0.5904
p.E76K	DO229211	THCA	ICGC	EEPSWVPSP	DEG_COP1_1	0.7022
p.A75T	ACH-000856	Breast Cancer	CCLE	EEPSWVPSP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N159	N-acetylglutamate synthase, mitochondrial	DEG_COP1_1	76:84	EEPSWVPSP	COP1	0.8778	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons