DegronMD - Q8N187(CARF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q374H	TCGA-A5-A0G2	UCEC	TCGA	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1111
p.H387N	DO223588	BLCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.7423
p.D383N	DO225215	BRCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.6932
p.D383N	DO227836	BRCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.6932
p.S394F	DO222644	MELA	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1667
p.S394F	DO47255	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1667
p.R396S	DO35424	PACA	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1111
p.I384T	DO36281	PRAD	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.7078
p.S376F	DO37519	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1667
p.P379S	DO37409	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.25
p.P395S	SIDM00189	Melanoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1389
p.P395S	ACH-002098	Skin Cancer	CCLE	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1389
p.P395S	CP67-MEL	skin	COSMIC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.1389
p.L382S	SIDM00845	Burkitt's Lymphoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.7667
p.S398F	SIDM00193	Colorectal Carcinoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.0556
p.S398F	ACH-000991	Colon/Colorectal Cancer	CCLE	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.0556
p.S398F	SNU-81	large intestine	COSMIC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation rewiring degron network	0.0556
p.P385R	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.7512
p.T386S	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	LETPCLT	DEG_SCF_FBW7_1	382:388	Mutation altering degron motif	0.7116

Kaplan plot for CARF in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CARF

UniProt ID: Q8N187

Entrez ID: 79800

Protein name: Calcium-responsive transcription factor (Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein) (Calcium-response factor) (CaRF) (Testis development protein NYD-SP24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CARF in