DegronMD

Uniprot ID: Q8N187

Source protein: Calcium-responsive transcription factor

Source gene: CARF

Class: DEG_SCF_FBW7_1

Location: 382:388

E3 ligase: FBXW7

DEGRON score: 0.9508

ASA_SCORE: 71.0857

COIL: 0.6697

CONS_SCORE: 0.3967

DSS_SCORE: 0.3904

HELIX: 0.1379

FCONS_SCORE: 0.7406

RIG_SCORE: 0.7779

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q374H	TCGA-A5-A0G2	UCEC	TCGA	LETPCLT	DEG_SCF_FBW7_1	0.1111
p.H387N	DO223588	BLCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.7423
p.D383N	DO225215	BRCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.6932
p.D383N	DO227836	BRCA	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.6932
p.S394F	DO222644	MELA	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.1667
p.S394F	DO47255	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.1667
p.R396S	DO35424	PACA	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.1111
p.I384T	DO36281	PRAD	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.7078
p.S376F	DO37519	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.1667
p.P379S	DO37409	SKCM	ICGC	LETPCLT	DEG_SCF_FBW7_1	0.25
p.P395S	SIDM00189	Melanoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	0.1389
p.P395S	ACH-002098	Skin Cancer	CCLE	LETPCLT	DEG_SCF_FBW7_1	0.1389
p.P395S	CP67-MEL	skin	COSMIC	LETPCLT	DEG_SCF_FBW7_1	0.1389
p.L382S	SIDM00845	Burkitt's Lymphoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	0.7667
p.S398F	SIDM00193	Colorectal Carcinoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	0.0556
p.S398F	ACH-000991	Colon/Colorectal Cancer	CCLE	LETPCLT	DEG_SCF_FBW7_1	0.0556
p.S398F	SNU-81	large_intestine	COSMIC	LETPCLT	DEG_SCF_FBW7_1	0.0556
p.P385R	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	LETPCLT	DEG_SCF_FBW7_1	0.7512
p.T386S	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	LETPCLT	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N187	Calcium-responsive transcription factor	DEG_SCF_FBW7_1	382:388	LETPCLT	FBXW7	0.9508	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons