DegronMD - Q8N1D5(CFAP107)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C172F	TCGA-78-7542	LUAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.5996
p.C172F	DO24760	LUAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.5996
p.Y162S	TCGA-AX-A0J0	UCEC	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.Y162S	DO41133	UCEC	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.A173T	TCGA-DD-AAEH	LIHC	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6028
p.A173T	DO227995	COCA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6028
p.A173T	DO52272	LIHC	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6028
p.S164L	TCGA-FW-A3R5	SKCM	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.S164L	TCGA-YG-AA3N	SKCM	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.S164L	DO228779	LICA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.S164L	DO222837	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.S164L	DO37406	SKCM	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.S164L	DO51298	SKCM	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.25
p.P185L	TCGA-R5-A805	STAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.P185L	DO222346	STAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0556
p.P167L	TCGA-VQ-A91E	STAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6471
p.P167L	DO51784	STAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6471
p.A180V	DO222539	ESCA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.A180V	DO228233	MALY	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.A180V	DO220850	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.A180V	SIDM00789	Colorectal Carcinoma	GDSC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1944
p.P169L	DO220900	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation altering degron motif	0.6471
p.P184S	DO222749	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.0833
p.P182L	SIDM00200	Ewing's Sarcoma	GDSC	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1389
p.P182L	ACH-002112	Bone Cancer	CCLE	PRPPLCAMS	DEG_APCC_DBOX_1	167:175	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CFAP107

UniProt ID: Q8N1D5

Entrez ID: 93190

Protein name: Protein CFAP107 (Cilia- and flagella-associated protein 107)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CFAP107 in