DegronMD

Uniprot ID: Q8N1D5

Source protein: Protein CFAP107

Source gene: CFAP107

Class: DEG_APCC_DBOX_1

Location: 167:175

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7952

ASA_SCORE: 71.3889

COIL: 0.7732

CONS_SCORE: 0.4714

DSS_SCORE: 0.3607

HELIX: 0.1746

FCONS_SCORE: 1.0156

RIG_SCORE: 0.6999

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C172F	TCGA-78-7542	LUAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.5996
p.C172F	DO24760	LUAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.5996
p.Y162S	TCGA-AX-A0J0	UCEC	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.Y162S	DO41133	UCEC	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.A173T	TCGA-DD-AAEH	LIHC	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.6028
p.A173T	DO227995	COCA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.6028
p.A173T	DO52272	LIHC	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.6028
p.S164L	TCGA-FW-A3R5	SKCM	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.S164L	TCGA-YG-AA3N	SKCM	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.S164L	DO228779	LICA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.S164L	DO222837	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.S164L	DO37406	SKCM	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.S164L	DO51298	SKCM	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.25
p.P185L	TCGA-R5-A805	STAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.0556
p.P185L	DO222346	STAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.0556
p.P167L	TCGA-VQ-A91E	STAD	TCGA	PRPPLCAMS	DEG_APCC_DBOX_1	0.6471
p.P167L	DO51784	STAD	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.6471
p.A180V	DO222539	ESCA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.A180V	DO228233	MALY	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.A180V	DO220850	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.A180V	SIDM00789	Colorectal Carcinoma	GDSC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1944
p.P169L	DO220900	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.6471
p.P184S	DO222749	MELA	ICGC	PRPPLCAMS	DEG_APCC_DBOX_1	0.0833
p.P182L	SIDM00200	Ewing's Sarcoma	GDSC	PRPPLCAMS	DEG_APCC_DBOX_1	0.1389
p.P182L	ACH-002112	Bone Cancer	CCLE	PRPPLCAMS	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1D5	Protein CFAP107	DEG_APCC_DBOX_1	167:175	PRPPLCAMS	APC,CDC20,FZR1	0.7952	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons