DegronMD - Q8N1M1(BEST3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q487P	TCGA-BR-4280	STAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.5924
p.E474D	TCGA-CG-4443	STAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation rewiring degron network	0.0556
p.L499M	TCGA-IB-7651	PAAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation rewiring degron network	0.0556
p.P487L	DO1678	BRCA	ICGC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.7582
p.P487L	DO40978	UCEC	ICGC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.7582
p.P476S	DO41871	UCEC	ICGC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation rewiring degron network	0.1111
p.K496N	SIDM00683	Prostate Carcinoma	GDSC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation substituting flanking lysine	0.25
p.K496N	ACH-000977	lymph node	CCLE	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation substituting flanking lysine	0.25
p.K496N	LNCaP-Clone-FGC	prostate	COSMIC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation substituting flanking lysine	0.25
p.S488P	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.5641
p.G488V	CAL-120	breast	COSMIC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.7532
p.L486I	HCC2998	large intestine	COSMIC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation altering degron motif	0.7174
p.R483M	HCT-15	large intestine	COSMIC	LTPQSS	DEG_SCF_FBW7_1	484:489	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons