DegronMD

Uniprot ID: Q8N1M1

Source protein: Bestrophin-3

Source gene: BEST3

Class: DEG_SCF_FBW7_1

Location: 484:489

E3 ligase: FBXW7

DEGRON score: 0.9836

ASA_SCORE: 100.1167

COIL: 0.9345

CONS_SCORE: 0.4385

DSS_SCORE: 0.5572

HELIX: 0.0497

FCONS_SCORE: 0.9994

RIG_SCORE: 0.6903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q487P	TCGA-BR-4280	STAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	0.5924
p.E474D	TCGA-CG-4443	STAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	0.0556
p.L499M	TCGA-IB-7651	PAAD	TCGA	LTPQSS	DEG_SCF_FBW7_1	0.0556
p.P487L	DO1678	BRCA	ICGC	LTPQSS	DEG_SCF_FBW7_1	0.7582
p.P487L	DO40978	UCEC	ICGC	LTPQSS	DEG_SCF_FBW7_1	0.7582
p.P476S	DO41871	UCEC	ICGC	LTPQSS	DEG_SCF_FBW7_1	0.1111
p.K496N	SIDM00683	Prostate Carcinoma	GDSC	LTPQSS	DEG_SCF_FBW7_1	0.25
p.K496N	ACH-000977	lymph_node	CCLE	LTPQSS	DEG_SCF_FBW7_1	0.25
p.K496N	LNCaP-Clone-FGC	prostate	COSMIC	LTPQSS	DEG_SCF_FBW7_1	0.25
p.S488P	ACH-000954	Endometrial/Uterine Cancer	CCLE	LTPQSS	DEG_SCF_FBW7_1	0.5641
p.G488V	CAL-120	breast	COSMIC	LTPQSS	DEG_SCF_FBW7_1	0.7532
p.L486I	HCC2998	large_intestine	COSMIC	LTPQSS	DEG_SCF_FBW7_1	0.7174
p.R483M	HCT-15	large_intestine	COSMIC	LTPQSS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N1M1	Bestrophin-3	DEG_SCF_FBW7_1	484:489	LTPQSS	FBXW7	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons