DegronMD - Q8N2H9(PELI3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V107I	TCGA-AA-A01R	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.2222
p.V107I	DO7934	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.2222
p.G102R	TCGA-CA-6717	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.0833
p.G102R	DO8264	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.0833
p.T113M	TCGA-HU-A4H8	STAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7423
p.T113M	DO47869	STAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7423
p.T113M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7423
p.T113M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7423
p.T113M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.7423
p.K104T	TCGA-WS-AB45	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation substituting flanking lysine	0.25
p.K104T	DO51734	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation substituting flanking lysine	0.25
p.M108I	DO229018	LICA	ICGC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.25
p.P114S	SIDM00498	Colorectal Carcinoma	GDSC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.6752
p.P114S	SNU-C5	large intestine	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation altering degron motif	0.6752
p.R123G	NCI-H650	lung	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.1667
p.Q118H	BT-474	breast	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	111:117	Mutation rewiring degron network	0.3056

Kaplan plot for PELI3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PELI3

UniProt ID: Q8N2H9

Entrez ID: 246330

Protein name: E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase pellino homolog 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PELI3 in