DegronMD

Uniprot ID: Q8N2H9

Source protein: E3 ubiquitin-protein ligase pellino homolog 3

Source gene: PELI3

Class: DEG_SCF_FBW7_1

Location: 111:117

E3 ligase: FBXW7

DEGRON score: 0.6901

ASA_SCORE: 55.8

COIL: 0.679

CONS_SCORE: 0.4452

DSS_SCORE: 0.47

HELIX: 0.1227

FCONS_SCORE: 0.9123

RIG_SCORE: 0.7667

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V107I	TCGA-AA-A01R	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	0.2222
p.V107I	DO7934	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	0.2222
p.G102R	TCGA-CA-6717	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	0.0833
p.G102R	DO8264	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	0.0833
p.T113M	TCGA-HU-A4H8	STAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	0.7423
p.T113M	DO47869	STAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	0.7423
p.T113M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ISTPLVS	DEG_SCF_FBW7_1	0.7423
p.T113M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ISTPLVS	DEG_SCF_FBW7_1	0.7423
p.T113M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	0.7423
p.K104T	TCGA-WS-AB45	COAD	TCGA	ISTPLVS	DEG_SCF_FBW7_1	0.25
p.K104T	DO51734	COAD	ICGC	ISTPLVS	DEG_SCF_FBW7_1	0.25
p.M108I	DO229018	LICA	ICGC	ISTPLVS	DEG_SCF_FBW7_1	0.25
p.P114S	SIDM00498	Colorectal Carcinoma	GDSC	ISTPLVS	DEG_SCF_FBW7_1	0.6752
p.P114S	SNU-C5	large_intestine	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	0.6752
p.R123G	NCI-H650	lung	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	0.1667
p.Q118H	BT-474	breast	COSMIC	ISTPLVS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2H9	E3 ubiquitin-protein ligase pellino homolog 3	DEG_SCF_FBW7_1	111:117	ISTPLVS	FBXW7	0.6901	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons