DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
ANKRD36B
UniProt ID:
Q8N2N9
Entrez ID:
57730
Protein name:
Ankyrin repeat domain-containing protein 36B (CLL-associated antigen KW-1)
External links:
UniprotKB
HGNC
RefSeq
COSMIC
Please click
HERE
for better display.
Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
...
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GO - Biological processes (BP):
...
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GO - Molecular function (MF):
identical protein binding [GO:0042802]...
identical protein binding [GO:0042802]
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GO - Cellular component (CC):
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Open in full screen with detailed sequence annotations
ANKRD36B
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.A719V
SIDM01664
Prostate Carcinoma
GDSC
VQTST
DEG_SPOP_SBC_1
725:729
Mutation rewiring degron network
0.1667
p.K721T
SIDM01450
Gastric Carcinoma
GDSC
VQTST
DEG_SPOP_SBC_1
725:729
Mutation substituting flanking lysine
0.3333
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for ANKRD36B in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc