DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
VQTST
Uniprot ID:
Q8N2N9
Source protein:
Ankyrin repeat domain-containing protein 36B
Source gene:
ANKRD36B
Class:
DEG_SPOP_SBC_1
Location:
725:729
E3 ligase:
SPOP
DEGRON score:
0.996
ASA_SCORE:
95.38
COIL:
0.8028
CONS_SCORE:
0.5166
DSS_SCORE:
0.6255
HELIX:
0.178
FCONS_SCORE:
1.0668
RIG_SCORE:
0.7042
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A719V
SIDM01664
Prostate Carcinoma
GDSC
VQTST
DEG_SPOP_SBC_1
0.1667
p.K721T
SIDM01450
Gastric Carcinoma
GDSC
VQTST
DEG_SPOP_SBC_1
0.3333
Drug responses associated with ANKRD36B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VQTST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N2N9
Ankyrin repeat domain-containing protein 36B
DEG_SPOP_SBC_1
725:729
VQTST
SPOP
0.996
More...
A6QL64
Ankyrin repeat domain-containing protein 36A
DEG_SPOP_SBC_1
1287:1291
VQTST
SPOP
0.7936
More...
Q5JPF3
Ankyrin repeat domain-containing protein 36C
DEG_SPOP_SBC_1
1151:1155
VQTST
SPOP
0.8174
More...