DegronMD - A6QL64(ANKRD36)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1296S	TCGA-UB-A7MB	LIHC	TCGA	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.T1296S	DO52318	LIHC	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.W1280G	DO222533	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229010	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229013	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229016	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229003	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229005	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO225404	LAML	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO228941	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO228950	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.W1280G	DO229121	THCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.P1287H	DO229054	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation altering degron motif	0.7694
p.T1284P	DO232761	PBCA	ICGC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.25
p.T1282A	SIDM00088	Prostate Carcinoma	GDSC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.T1282A	SIDM01136	Pancreatic Carcinoma	GDSC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.T1282A	SIDM01105	Melanoma	GDSC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.T1282A	SIDM00100	Mesothelioma	GDSC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1944
p.A1326S	ACH-000015	Lung Cancer	CCLE	SRDDLDDII	DEG_APCC_DBOX_1	1324:1332	Mutation altering degron motif	0.7588
p.T1277I	ACH-000483	Liver Cancer	CCLE	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.0556
p.E1298Q	ACH-000809	Esophageal Cancer	CCLE	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389
p.E1298Q	KYSE-410	oesophagus	COSMIC	VQTST	DEG_SPOP_SBC_1	1287:1291	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKRD36

UniProt ID: A6QL64

Entrez ID: 375248

Protein name: Ankyrin repeat domain-containing protein 36A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ANKRD36 in