DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SRDDLDDII
Uniprot ID:
A6QL64
Source protein:
Ankyrin repeat domain-containing protein 36A
Source gene:
ANKRD36
Class:
DEG_APCC_DBOX_1
Location:
1324:1332
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8993
ASA_SCORE:
86.1111
COIL:
0.6849
CONS_SCORE:
0.3446
DSS_SCORE:
0.5151
HELIX:
0.2389
FCONS_SCORE:
1.0293
RIG_SCORE:
0.7646
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1326S
ACH-000015
Lung Cancer
CCLE
SRDDLDDII
DEG_APCC_DBOX_1
0.7588
Drug responses associated with ANKRD36 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SRDDLDDII
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A6QL64
Ankyrin repeat domain-containing protein 36A
DEG_APCC_DBOX_1
1324:1332
SRDDLDDII
APC,CDC20,FZR1
0.8993
More...