DegronMD

Uniprot ID: A6QL64

Source protein: Ankyrin repeat domain-containing protein 36A

Source gene: ANKRD36

Class: DEG_SPOP_SBC_1

Location: 1287:1291

E3 ligase: SPOP

DEGRON score: 0.7936

ASA_SCORE: 97.84

COIL: 0.856

CONS_SCORE: 0.3129

DSS_SCORE: 0.6193

HELIX: 0.099

FCONS_SCORE: 0.9683

RIG_SCORE: 0.7027

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1296S	TCGA-UB-A7MB	LIHC	TCGA	VQTST	DEG_SPOP_SBC_1	0.1944
p.T1296S	DO52318	LIHC	ICGC	VQTST	DEG_SPOP_SBC_1	0.1944
p.W1280G	DO222533	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229010	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229013	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229016	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229003	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229005	COCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO225404	LAML	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO228941	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO228950	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.W1280G	DO229121	THCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.1389
p.P1287H	DO229054	LICA	ICGC	VQTST	DEG_SPOP_SBC_1	0.7694
p.T1284P	DO232761	PBCA	ICGC	VQTST	DEG_SPOP_SBC_1	0.25
p.T1282A	SIDM00088	Prostate Carcinoma	GDSC	VQTST	DEG_SPOP_SBC_1	0.1944
p.T1282A	SIDM01136	Pancreatic Carcinoma	GDSC	VQTST	DEG_SPOP_SBC_1	0.1944
p.T1282A	SIDM01105	Melanoma	GDSC	VQTST	DEG_SPOP_SBC_1	0.1944
p.T1282A	SIDM00100	Mesothelioma	GDSC	VQTST	DEG_SPOP_SBC_1	0.1944
p.T1277I	ACH-000483	Liver Cancer	CCLE	VQTST	DEG_SPOP_SBC_1	0.0556
p.E1298Q	ACH-000809	Esophageal Cancer	CCLE	VQTST	DEG_SPOP_SBC_1	0.1389
p.E1298Q	KYSE-410	oesophagus	COSMIC	VQTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N2N9	Ankyrin repeat domain-containing protein 36B	DEG_SPOP_SBC_1	725:729	VQTST	SPOP	0.996	More...
A6QL64	Ankyrin repeat domain-containing protein 36A	DEG_SPOP_SBC_1	1287:1291	VQTST	SPOP	0.7936	More...
Q5JPF3	Ankyrin repeat domain-containing protein 36C	DEG_SPOP_SBC_1	1151:1155	VQTST	SPOP	0.8174	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons