CIART
UniProt ID: Q8N365
Entrez ID: 148523
Protein name: Circadian-associated transcriptional repressor (ChIP-derived repressor of network oscillator) (Chrono) (Computationally highlighted repressor of the network oscillator)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-A...
FUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Abrogates the interaction of ARNTL/BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-ARNTL/BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to ARNTL/BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response (By similarity). {ECO:0000250}.
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GO - Biological processes (BP):
circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; negative regulation of transcription, DNA-templated [GO:0045892]...
circadian regulation of gene expression [GO:0032922]; locomotor rhythm [GO:0045475]; negative regulation of transcription, DNA-templated [GO:0045892]
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GO - Molecular function (MF):
E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]...
E-box binding [GO:0070888]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]
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GO - Cellular component (CC):
nucleus [GO:0005634]; PML body [GO:0016605]...
nucleus [GO:0005634]; PML body [GO:0016605]
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CIART
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*NOTE: the Kaplan plots were collected from OncoLnc