DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DWSYTLSP
Uniprot ID:
Q8N365
Source protein:
Circadian-associated transcriptional repressor
Source gene:
CIART
Class:
CBL_PTK
Location:
345:352
E3 ligase:
CBL
DEGRON score:
0.9804
ASA_SCORE:
76.825
COIL:
0.7449
CONS_SCORE:
0.4351
DSS_SCORE:
0.3676
HELIX:
0.0926
FCONS_SCORE:
0.927
RIG_SCORE:
0.7369
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T341N
SIDM00683
Prostate Carcinoma
GDSC
DWSYTLSP
CBL_PTK
0.2222
p.M362I
SIDM00387
Neuroblastoma
GDSC
DWSYTLSP
CBL_PTK
0.0556
p.M362I
MHH-NB-11
autonomic_ganglia
COSMIC
DWSYTLSP
CBL_PTK
0.0556
Drug responses associated with CIART mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DWSYTLSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N365
Circadian-associated transcriptional repressor
CBL_PTK
345:352
DWSYTLSP
CBL
0.9804
More...
