DegronMD - Q8N386(LRRC25)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A251G	TCGA-86-8073	LUAD	TCGA	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1111
p.A251G	DO23624	LUAD	ICGC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1111
p.V231L	TCGA-EY-A1GD	UCEC	TCGA	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1667
p.V231L	DO42129	UCEC	ICGC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1667
p.G248R	TCGA-NC-A5HL	LUSC	TCGA	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1944
p.G248R	DO219193	LUSC	ICGC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1944
p.K228N	DO232224	PBCA	ICGC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation substituting flanking lysine	0.1944
p.V233M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.2222
p.V233M	ACH-000995	Leukemia	CCLE	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.2222
p.V233M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.2222
p.P234T	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.P234T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.P234T	SIDM00200	Ewing's Sarcoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.P234T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.P234T	SIDM00479	Esophageal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.P234T	SIDM01140	Ovarian Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.25
p.D241G	SIDM00834	Colorectal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation altering degron motif	0.6087
p.D241G	ACH-000470	Colon/Colorectal Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation altering degron motif	0.6087
p.P250S	SIDM00217	Colorectal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1389
p.P250S	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1389
p.P250S	SNU-1040	large intestine	COSMIC	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.1389
p.K228Q	ACH-000555	Kidney Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation substituting flanking lysine	0.1944
p.N244S	ACH-000961	Endometrial/Uterine Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	237:243	Mutation rewiring degron network	0.3056

Kaplan plot for LRRC25 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC25

UniProt ID: Q8N386

Entrez ID: 126364

Protein name: Leucine-rich repeat-containing protein 25 (Monocyte and plasmacytoid-activated protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC25 in