DegronMD

Uniprot ID: Q8N386

Source protein: Leucine-rich repeat-containing protein 25

Source gene: LRRC25

Class: DEG_SCF_FBW7_2

Location: 237:243

E3 ligase: FBXW7

DEGRON score: 0.9777

ASA_SCORE: 77.3

COIL: 0.7919

CONS_SCORE: 0.8018

DSS_SCORE: 0.5385

HELIX: 0.1541

FCONS_SCORE: 1.2293

RIG_SCORE: 0.6809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A251G	TCGA-86-8073	LUAD	TCGA	PSTPDYE	DEG_SCF_FBW7_2	0.1111
p.A251G	DO23624	LUAD	ICGC	PSTPDYE	DEG_SCF_FBW7_2	0.1111
p.V231L	TCGA-EY-A1GD	UCEC	TCGA	PSTPDYE	DEG_SCF_FBW7_2	0.1667
p.V231L	DO42129	UCEC	ICGC	PSTPDYE	DEG_SCF_FBW7_2	0.1667
p.G248R	TCGA-NC-A5HL	LUSC	TCGA	PSTPDYE	DEG_SCF_FBW7_2	0.1944
p.G248R	DO219193	LUSC	ICGC	PSTPDYE	DEG_SCF_FBW7_2	0.1944
p.K228N	DO232224	PBCA	ICGC	PSTPDYE	DEG_SCF_FBW7_2	0.1944
p.V233M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.2222
p.V233M	ACH-000995	Leukemia	CCLE	PSTPDYE	DEG_SCF_FBW7_2	0.2222
p.V233M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPDYE	DEG_SCF_FBW7_2	0.2222
p.P234T	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.P234T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.P234T	SIDM00200	Ewing's Sarcoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.P234T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.P234T	SIDM00479	Esophageal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.P234T	SIDM01140	Ovarian Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.25
p.D241G	SIDM00834	Colorectal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.6087
p.D241G	ACH-000470	Colon/Colorectal Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	0.6087
p.P250S	SIDM00217	Colorectal Carcinoma	GDSC	PSTPDYE	DEG_SCF_FBW7_2	0.1389
p.P250S	ACH-000999	Colon/Colorectal Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	0.1389
p.P250S	SNU-1040	large_intestine	COSMIC	PSTPDYE	DEG_SCF_FBW7_2	0.1389
p.K228Q	ACH-000555	Kidney Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	0.1944
p.N244S	ACH-000961	Endometrial/Uterine Cancer	CCLE	PSTPDYE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N386	Leucine-rich repeat-containing protein 25	DEG_SCF_FBW7_2	237:243	PSTPDYE	FBXW7	0.9777	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPDYE

Degron related mutations and impact score

Drug responses associated with LRRC25 mutations

All proteins holding degron of PSTPDYE