DegronMD - Q8N392(ARHGAP18)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G213V	TCGA-21-1082	LUSC	TCGA	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1389
p.G213V	DO26463	LUSC	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1389
p.E221Q	TCGA-AO-A03M	BRCA	TCGA	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.5633
p.E221Q	DO2216	BRCA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.5633
p.E215D	TCGA-D1-A103	UCEC	TCGA	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1944
p.E215D	DO42312	UCEC	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1944
p.N231D	TCGA-D3-A5GU	SKCM	TCGA	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.2222
p.N231D	DO47584	SKCM	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.2222
p.E215K	TCGA-GF-A6C8	SKCM	TCGA	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1944
p.E215K	DO48765	SKCM	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1944
p.T223M	DO222765	COCA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.7423
p.A237D	DO229037	LICA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.0556
p.E221A	SIDM00596	Endometrial Carcinoma	GDSC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.659
p.E221A	ACH-001517	Endometrial/Uterine Cancer	CCLE	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.659
p.E221A	HEC-1	endometrium	COSMIC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation altering degron motif	0.659
p.V234L	SIDM00524	Small Cell Lung Carcinoma	GDSC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1389
p.V234L	ACH-000703	Lung Cancer	CCLE	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1389
p.V234L	DMS-79	lung	COSMIC	PEETPAPE	DEG_SCF_FBW7_2	220:227	Mutation rewiring degron network	0.1389

Kaplan plot for ARHGAP18 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP18

UniProt ID: Q8N392

Entrez ID: 93663

Protein name: Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGAP18 in