DegronMD

Uniprot ID: Q8N392

Source protein: Rho GTPase-activating protein 18

Source gene: ARHGAP18

Class: DEG_SCF_FBW7_2

Location: 220:227

E3 ligase: FBXW7

DEGRON score: 0.7052

ASA_SCORE: 91.9375

COIL: 0.8879

CONS_SCORE: 0.4083

DSS_SCORE: 0.6753

HELIX: 0.08

FCONS_SCORE: 0.9965

RIG_SCORE: 0.6547

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G213V	TCGA-21-1082	LUSC	TCGA	PEETPAPE	DEG_SCF_FBW7_2	0.1389
p.G213V	DO26463	LUSC	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.1389
p.E221Q	TCGA-AO-A03M	BRCA	TCGA	PEETPAPE	DEG_SCF_FBW7_2	0.5633
p.E221Q	DO2216	BRCA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.5633
p.E215D	TCGA-D1-A103	UCEC	TCGA	PEETPAPE	DEG_SCF_FBW7_2	0.1944
p.E215D	DO42312	UCEC	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.1944
p.N231D	TCGA-D3-A5GU	SKCM	TCGA	PEETPAPE	DEG_SCF_FBW7_2	0.2222
p.N231D	DO47584	SKCM	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.2222
p.E215K	TCGA-GF-A6C8	SKCM	TCGA	PEETPAPE	DEG_SCF_FBW7_2	0.1944
p.E215K	DO48765	SKCM	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.1944
p.T223M	DO222765	COCA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.7423
p.A237D	DO229037	LICA	ICGC	PEETPAPE	DEG_SCF_FBW7_2	0.0556
p.E221A	SIDM00596	Endometrial Carcinoma	GDSC	PEETPAPE	DEG_SCF_FBW7_2	0.659
p.E221A	ACH-001517	Endometrial/Uterine Cancer	CCLE	PEETPAPE	DEG_SCF_FBW7_2	0.659
p.E221A	HEC-1	endometrium	COSMIC	PEETPAPE	DEG_SCF_FBW7_2	0.659
p.V234L	SIDM00524	Small Cell Lung Carcinoma	GDSC	PEETPAPE	DEG_SCF_FBW7_2	0.1389
p.V234L	ACH-000703	Lung Cancer	CCLE	PEETPAPE	DEG_SCF_FBW7_2	0.1389
p.V234L	DMS-79	lung	COSMIC	PEETPAPE	DEG_SCF_FBW7_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N392	Rho GTPase-activating protein 18	DEG_SCF_FBW7_2	220:227	PEETPAPE	FBXW7	0.7052	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons