DegronMD - Q8N3I7(BBS5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R312C	TCGA-B5-A11N	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.8301
p.R312C	TCGA-BS-A0UF	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.8301
p.R312C	TCGA-EI-6917	READ	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.8301
p.R312C	TCGA-EO-A22U	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.8301
p.I324V	TCGA-DI-A1BU	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1667
p.E315K	DO838	BLCA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation altering degron motif	0.7022
p.F303Y	DO233215	GACA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.0833
p.A302E	DO233728	GACA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.0556
p.Y302C	DO48677	LIRI	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.0556
p.S324L	DO25957	LUAD	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.1667
p.P321H	DO220185	SARC	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.25
p.I303V	DO42023	UCEC	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.0833
p.G309E	NCI-H1876	lung	COSMIC	REPVFSE	LIG_APCC_ABBAyCdc20_2	312:318	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons