DegronMD

Uniprot ID: Q8N3I7

Source protein: Bardet-Biedl syndrome 5 protein

Source gene: BBS5

Class: LIG_APCC_ABBAyCdc20_2

Location: 312:318

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9077

ASA_SCORE: 75.7857

COIL: 0.8063

CONS_SCORE: 0.5304

DSS_SCORE: 0.3859

HELIX: 0.0283

FCONS_SCORE: 0.941

RIG_SCORE: 0.8189

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R312C	TCGA-B5-A11N	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R312C	TCGA-BS-A0UF	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R312C	TCGA-EI-6917	READ	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R312C	TCGA-EO-A22U	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.8301
p.I324V	TCGA-DI-A1BU	UCEC	TCGA	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E315K	DO838	BLCA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.7022
p.F303Y	DO233215	GACA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A302E	DO233728	GACA	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Y302C	DO48677	LIRI	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S324L	DO25957	LUAD	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.P321H	DO220185	SARC	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.25
p.I303V	DO42023	UCEC	ICGC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G309E	NCI-H1876	lung	COSMIC	REPVFSE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3I7	Bardet-Biedl syndrome 5 protein	LIG_APCC_ABBAyCdc20_2	312:318	REPVFSE	APC,CDC20,FZR1	0.9077	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons