DegronMD - Q8N3P4(VPS8)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K120N	TCGA-AA-3977	COAD	TCGA	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.2778
p.K120N	DO8730	COAD	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.2778
p.K120N	DO228627	GACA	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.2778
p.K120N	DO36881	READ	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.2778
p.D101A	TCGA-BS-A0UV	UCEC	TCGA	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.1111
p.D101A	DO42793	UCEC	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.1111
p.S104Y	TCGA-GN-A265	SKCM	TCGA	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.1944
p.S104Y	DO37491	SKCM	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.1944
p.G111D	DO234230	ESAD	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation altering degron motif	0.7198
p.S107I	DO228924	LICA	ICGC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation rewiring degron network	0.2778
p.D112N	SIDM01770	Gastric Carcinoma	GDSC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation altering degron motif	0.5821
p.D112N	ACH-000908	Gastric Cancer	CCLE	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation altering degron motif	0.5821
p.K121N	SIDM01611	Endometrial Carcinoma	GDSC	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.25
p.K121N	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGDRT	DEG_SCF_TRCP1_1	109:114	Mutation substituting flanking lysine	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons