DegronMD

Uniprot ID: Q8N3P4

Source protein: Vacuolar protein sorting-associated protein 8 homolog

Source gene: VPS8

Class: DEG_SCF_TRCP1_1

Location: 109:114

E3 ligase: BTRC

DEGRON score: 0.7926

ASA_SCORE: 85.0833

COIL: 0.796

CONS_SCORE: 0.2284

DSS_SCORE: 0.5419

HELIX: 0.1565

FCONS_SCORE: 1.0095

RIG_SCORE: 0.6313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K120N	TCGA-AA-3977	COAD	TCGA	DSGDRT	DEG_SCF_TRCP1_1	0.2778
p.K120N	DO8730	COAD	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.2778
p.K120N	DO228627	GACA	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.2778
p.K120N	DO36881	READ	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.2778
p.D101A	TCGA-BS-A0UV	UCEC	TCGA	DSGDRT	DEG_SCF_TRCP1_1	0.1111
p.D101A	DO42793	UCEC	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.1111
p.S104Y	TCGA-GN-A265	SKCM	TCGA	DSGDRT	DEG_SCF_TRCP1_1	0.1944
p.S104Y	DO37491	SKCM	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.1944
p.G111D	DO234230	ESAD	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.7198
p.S107I	DO228924	LICA	ICGC	DSGDRT	DEG_SCF_TRCP1_1	0.2778
p.D112N	SIDM01770	Gastric Carcinoma	GDSC	DSGDRT	DEG_SCF_TRCP1_1	0.5821
p.D112N	ACH-000908	Gastric Cancer	CCLE	DSGDRT	DEG_SCF_TRCP1_1	0.5821
p.K121N	SIDM01611	Endometrial Carcinoma	GDSC	DSGDRT	DEG_SCF_TRCP1_1	0.25
p.K121N	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGDRT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3P4	Vacuolar protein sorting-associated protein 8 homolog	DEG_SCF_TRCP1_1	109:114	DSGDRT	BTRC	0.7926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons