DegronMD - Q8N3U4(STAG2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1129S	TCGA-21-5782	LUSC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1389
p.P1129S	TCGA-BH-A0AW	BRCA	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1389
p.P1129S	DO5005	BRCA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1389
p.P1129S	DO27120	LUSC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1389
p.T1122A	TCGA-A5-A2K5	UCEC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation altering degron motif	0.7139
p.T1122A	DO41379	UCEC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation altering degron motif	0.7139
p.E1128D	TCGA-AX-A0J1	UCEC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1667
p.E1128D	DO41199	UCEC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1667
p.M1116I	DO228971	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation altering degron motif	0.6507
p.M1116I	DO229035	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation altering degron motif	0.6507
p.M1115I	DO229022	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation altering degron motif	0.6507
p.K1130N	DO27939	ORCA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation substituting flanking lysine	0.2222
p.T1124N	SIDM00079	Ovarian Carcinoma	GDSC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation blocking phosphorylation signal	0.7222
p.T1124N	ACH-000811	Ovarian Cancer	CCLE	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation blocking phosphorylation signal	0.7222
p.T1124N	SK-OV-3	ovary	COSMIC	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation blocking phosphorylation signal	0.7222
p.E1107D	ACH-000901	Lung Cancer	CCLE	MMQTPQLT	DEG_SCF_FBW7_1	1115:1122	Mutation rewiring degron network	0.1111

Kaplan plot for STAG2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STAG2

UniProt ID: Q8N3U4

Entrez ID: 10735

Protein name: Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STAG2 in