DegronMD

Uniprot ID: Q8N3U4

Source protein: Cohesin subunit SA-2

Source gene: STAG2

Class: DEG_SCF_FBW7_1

Location: 1115:1122

E3 ligase: FBXW7

DEGRON score: 0.9771

ASA_SCORE: 97.65

COIL: 0.8861

CONS_SCORE: 0.2501

DSS_SCORE: 0.6188

HELIX: 0.0594

FCONS_SCORE: 0.9983

RIG_SCORE: 0.7355

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1129S	TCGA-21-5782	LUSC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	0.1389
p.P1129S	TCGA-BH-A0AW	BRCA	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	0.1389
p.P1129S	DO5005	BRCA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.1389
p.P1129S	DO27120	LUSC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.1389
p.T1122A	TCGA-A5-A2K5	UCEC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	0.7139
p.T1122A	DO41379	UCEC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.7139
p.E1128D	TCGA-AX-A0J1	UCEC	TCGA	MMQTPQLT	DEG_SCF_FBW7_1	0.1667
p.E1128D	DO41199	UCEC	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.1667
p.M1116I	DO228971	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.6507
p.M1116I	DO229035	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.6507
p.M1115I	DO229022	LICA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.6507
p.K1130N	DO27939	ORCA	ICGC	MMQTPQLT	DEG_SCF_FBW7_1	0.2222
p.T1124N	SIDM00079	Ovarian Carcinoma	GDSC	MMQTPQLT	DEG_SCF_FBW7_1	0.7222
p.T1124N	ACH-000811	Ovarian Cancer	CCLE	MMQTPQLT	DEG_SCF_FBW7_1	0.7222
p.T1124N	SK-OV-3	ovary	COSMIC	MMQTPQLT	DEG_SCF_FBW7_1	0.7222
p.E1107D	ACH-000901	Lung Cancer	CCLE	MMQTPQLT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3U4	Cohesin subunit SA-2	DEG_SCF_FBW7_1	1115:1122	MMQTPQLT	FBXW7	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons