DegronMD - Q8N3Y3(LARGE2)

LARGE2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R677C	SIDM01004	Chronic Myelogenous Leukemia	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation rewiring degron network	0.1944
p.R677C	SIDM01450	Gastric Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation rewiring degron network	0.1944
p.R677C	SIDM01782	Oral Cavity Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation rewiring degron network	0.1944
p.A688T	SIDM00516	Melanoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation altering degron motif	0.6028
p.A688T	SIDM01879	Non-Cancerous	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation altering degron motif	0.6028
p.L686R	SIDM00954	Breast Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation altering degron motif	0.8428
p.L686R	COLO-824	breast	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation altering degron motif	0.8428
p.T681N	SIDM00167	Head and Neck Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation blocking phosphorylation signal	0.75
p.A680T	DBTRG-05MG	central nervous system	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation rewiring degron network	0.2778
p.K676R	SNU-61	large intestine	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	682:690	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc