DegronMD

Uniprot ID: Q8N3Y3

Source protein: Xylosyl- and glucuronyltransferase LARGE2

Source gene: LARGE2

Class: DEG_APCC_DBOX_1

Location: 682:690

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8301

ASA_SCORE: 44.6111

COIL: 0.0149

CONS_SCORE: 0.3529

DSS_SCORE: 0.3031

HELIX: 0.9837

FCONS_SCORE: 1.1735

RIG_SCORE: 0.7936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R677C	SIDM01004	Chronic Myelogenous Leukemia	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.1944
p.R677C	SIDM01450	Gastric Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.1944
p.R677C	SIDM01782	Oral Cavity Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.1944
p.A688T	SIDM00516	Melanoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.6028
p.A688T	SIDM01879	Non-Cancerous	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.6028
p.L686R	SIDM00954	Breast Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.8428
p.L686R	COLO-824	breast	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	0.8428
p.T681N	SIDM00167	Head and Neck Carcinoma	GDSC	YRDCLQALK	DEG_APCC_DBOX_1	0.75
p.A680T	DBTRG-05MG	central_nervous_system	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	0.2778
p.K676R	SNU-61	large_intestine	COSMIC	YRDCLQALK	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3Y3	Xylosyl- and glucuronyltransferase LARGE2	DEG_APCC_DBOX_1	682:690	YRDCLQALK	APC,CDC20,FZR1	0.8301	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons