DegronMD - Q8N3Z0(PRSS35)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K190N	TCGA-05-4410	LUAD	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.5806
p.K190N	DO25426	LUAD	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.5806
p.V178A	TCGA-06-5416	GBM	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.V178A	DO10880	GBM	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1667
p.S195R	TCGA-34-2609	LUSC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.S195R	TCGA-EO-A22R	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.S195R	TCGA-LN-A49Y	ESCA	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.S195R	DO26981	LUSC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.S195R	DO42713	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.25
p.K175N	TCGA-AG-A002	READ	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation substituting flanking lysine	0.1944
p.K194T	TCGA-AJ-A3EL	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2778
p.K194T	DO41542	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.2778
p.R185S	TCGA-E6-A1LX	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.7427
p.R185S	DO41020	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.7427
p.R185S	ACH-002044	Head and Neck Cancer	CCLE	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.7427
p.G174V	DO229028	LICA	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.0556
p.L189F	DO229031	LICA	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation altering degron motif	0.587
p.R200H	SIDM02015	Colorectal Carcinoma	GDSC	LRVGLLKMR	DEG_APCC_DBOX_1	184:192	Mutation rewiring degron network	0.1111

Kaplan plot for PRSS35 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRSS35

UniProt ID: Q8N3Z0

Entrez ID: 167681

Protein name: Inactive serine protease 35

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRSS35 in