DegronMD

Uniprot ID: Q8N3Z0

Source protein: Inactive serine protease 35

Source gene: PRSS35

Class: DEG_APCC_DBOX_1

Location: 184:192

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.663

ASA_SCORE: 49.1667

COIL: 0.422

CONS_SCORE: 0.5535

DSS_SCORE: 0.5939

HELIX: 0.0386

FCONS_SCORE: 1.0432

RIG_SCORE: 0.801

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K190N	TCGA-05-4410	LUAD	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.5806
p.K190N	DO25426	LUAD	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.5806
p.V178A	TCGA-06-5416	GBM	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.1667
p.V178A	DO10880	GBM	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.1667
p.S195R	TCGA-34-2609	LUSC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.25
p.S195R	TCGA-EO-A22R	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.25
p.S195R	TCGA-LN-A49Y	ESCA	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.25
p.S195R	DO26981	LUSC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.25
p.S195R	DO42713	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.25
p.K175N	TCGA-AG-A002	READ	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.1944
p.K194T	TCGA-AJ-A3EL	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.2778
p.K194T	DO41542	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.2778
p.R185S	TCGA-E6-A1LX	UCEC	TCGA	LRVGLLKMR	DEG_APCC_DBOX_1	0.7427
p.R185S	DO41020	UCEC	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.7427
p.R185S	ACH-002044	Head and Neck Cancer	CCLE	LRVGLLKMR	DEG_APCC_DBOX_1	0.7427
p.G174V	DO229028	LICA	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.0556
p.L189F	DO229031	LICA	ICGC	LRVGLLKMR	DEG_APCC_DBOX_1	0.587
p.R200H	SIDM02015	Colorectal Carcinoma	GDSC	LRVGLLKMR	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N3Z0	Inactive serine protease 35	DEG_APCC_DBOX_1	184:192	LRVGLLKMR	APC,CDC20,FZR1	0.663	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons