DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
RIBC1
UniProt ID:
Q8N443
Entrez ID:
158787
Protein name:
RIB43A-like with coiled-coils protein 1
External links:
UniprotKB
HGNC
RefSeq
COSMIC
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Functional annotation
Mutations
Degrons
Degron mutations
Network-rewiring
Drug response
Drug resistance
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GO - Biological processes (BP):
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GO - Molecular function (MF):
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GO - Cellular component (CC):
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Choose a PDB ID:
Open in full screen with detailed sequence annotations
RIBC1
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CCLE
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AAchange
Cancer
Sample
Mutation type
Dataset
Degron hit
Class
E3 ligase
Source protein
Location
Detail
Mutation
Sample
Cancer
Degron hit
Class
Location
Dataset
Mutation
Sample
Cancer
Dataset
Degron hit
Class
Location
Type
Impact score
p.Q354R
TCGA-CG-4465
STAD
TCGA
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.2222
p.Q354R
DO38627
STAD
ICGC
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.2222
p.H371Y
TCGA-UC-A7PF
CESC
TCGA
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.1944
p.H371Y
DO49987
CESC
ICGC
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.1944
p.Q350K
SIDM01780
B-Cell Non-Hodgkin's Lymphoma
GDSC
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.1111
p.Q350K
ACH-000388
Lymphoma
CCLE
NSVIYTNQP
CBL_PTK
358:366
Mutation rewiring degron network
0.1111
Cell ID
Cell name
Cancer
Drug
IC50(uM)
Dataset
Protein
Degron
Cancer code
Cancer type
Drug
AVG_IC50(uM)(mutated)
AVG_IC50(uM)(Non-mutated)
Details
Kaplan plot for RIBC1 in
Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from
OncoLnc