DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NSVIYTNQP
Uniprot ID:
Q8N443
Source protein:
RIB43A-like with coiled-coils protein 1
Source gene:
RIBC1
Class:
CBL_PTK
Location:
358:366
E3 ligase:
CBL
DEGRON score:
0.9423
ASA_SCORE:
73.6778
COIL:
0.7136
CONS_SCORE:
0.5692
DSS_SCORE:
0.3858
HELIX:
0.2537
FCONS_SCORE:
1.0824
RIG_SCORE:
0.7887
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q354R
TCGA-CG-4465
STAD
TCGA
NSVIYTNQP
CBL_PTK
0.2222
p.Q354R
DO38627
STAD
ICGC
NSVIYTNQP
CBL_PTK
0.2222
p.H371Y
TCGA-UC-A7PF
CESC
TCGA
NSVIYTNQP
CBL_PTK
0.1944
p.H371Y
DO49987
CESC
ICGC
NSVIYTNQP
CBL_PTK
0.1944
p.Q350K
SIDM01780
B-Cell Non-Hodgkin's Lymphoma
GDSC
NSVIYTNQP
CBL_PTK
0.1111
p.Q350K
ACH-000388
Lymphoma
CCLE
NSVIYTNQP
CBL_PTK
0.1111
Drug responses associated with RIBC1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSVIYTNQP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8N443
RIB43A-like with coiled-coils protein 1
CBL_PTK
358:366
NSVIYTNQP
CBL
0.9423
More...
