DegronMD - Q8N461(FBXL16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L30M	TCGA-CM-5861	COAD	TCGA	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.L30M	DO7918	COAD	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.P24Q	DO229008	LICA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.5924
p.A22S	DO44990	LIHC	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.7588
p.W25L	DO37956	SKCM	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.3056
p.D9Y	DO229253	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.S34N	DO229272	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0556
p.P10A	DO229204	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.A32V	DO229211	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1111
p.A30S	DO229242	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1667
p.A33V	DO229542	UTCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.0833
p.C14G	ACH-001540	Liposarcoma	CCLE	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.G7A	NCI-H345	lung	COSMIC	PRNGLVKLP	DEG_APCC_DBOX_1	16:24	Mutation substituting flanking lysine	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons