DegronMD

Uniprot ID: Q8N461

Source protein: F-box/LRR-repeat protein 16

Source gene: FBXL16

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9728

ASA_SCORE: 78.8667

COIL: 0.7642

CONS_SCORE: 0.5018

DSS_SCORE: 0.6475

HELIX: 0.0504

FCONS_SCORE: 0.9643

RIG_SCORE: 0.7001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L30M	TCGA-CM-5861	COAD	TCGA	PRNGLVKLP	DEG_APCC_DBOX_1	0.1667
p.L30M	DO7918	COAD	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1667
p.P24Q	DO229008	LICA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.5924
p.A22S	DO44990	LIHC	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.7588
p.W25L	DO37956	SKCM	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.3056
p.D9Y	DO229253	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1389
p.S34N	DO229272	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.0556
p.P10A	DO229204	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1667
p.A32V	DO229211	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1111
p.A30S	DO229242	THCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1667
p.A33V	DO229542	UTCA	ICGC	PRNGLVKLP	DEG_APCC_DBOX_1	0.0833
p.C14G	ACH-001540	Liposarcoma	CCLE	PRNGLVKLP	DEG_APCC_DBOX_1	0.2778
p.G7A	NCI-H345	lung	COSMIC	PRNGLVKLP	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N461	F-box/LRR-repeat protein 16	DEG_APCC_DBOX_1	16:24	PRNGLVKLP	APC,CDC20,FZR1	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons