DegronMD - Q8N465(D2HGDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P141A	TCGA-12-0829	GBM	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6392
p.M153T	TCGA-76-4935	GBM	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.V142I	TCGA-AX-A0J1	UCEC	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.5965
p.P141L	TCGA-D3-A1QA	SKCM	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6471
p.P141L	SIDM01228	Melanoma	GDSC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6471
p.P141L	ACH-000931	Skin Cancer	CCLE	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6471
p.P141L	ACH-001024	Skin Cancer	CCLE	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6471
p.R155W	TCGA-EO-A22U	UCEC	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.R152H	TCGA-IB-7651	PAAD	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389
p.E145K	TCGA-IG-A51D	ESCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7022
p.T150I	TCGA-L5-A8NH	ESCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1944
p.S139N	TCGA-ZF-AA4W	BLCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.3056
p.F155Y	DO5500	BRCA	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.V134M	DO219795	LGG	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.V145L	DO229026	LICA	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6765
p.G131V	DO23414	LINC	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0833
p.R143S	DO45465	LUSC	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7427
p.F149S	DO219466	SKCM	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.R143M	DO229259	THCA	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.8632
p.A148V	DO42023	UCEC	ICGC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.P140L	SW1417	large intestine	COSMIC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7582
p.C152S	HCC1569	breast	COSMIC	VPVFDE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389

Kaplan plot for D2HGDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

D2HGDH

UniProt ID: Q8N465

Entrez ID: 728294

Protein name: D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for D2HGDH in