DegronMD

Uniprot ID: Q8N465

Source protein: D-2-hydroxyglutarate dehydrogenase, mitochondrial

Source gene: D2HGDH

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5648

ASA_SCORE: 51.85

COIL: 0.7403

CONS_SCORE: 0.6572

DSS_SCORE: 0.1693

HELIX: 0.0095

FCONS_SCORE: 0.9477

RIG_SCORE: 0.8948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P141A	TCGA-12-0829	GBM	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.6392
p.M153T	TCGA-76-4935	GBM	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.1111
p.V142I	TCGA-AX-A0J1	UCEC	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.5965
p.P141L	TCGA-D3-A1QA	SKCM	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.6471
p.P141L	SIDM01228	Melanoma	GDSC	VPVFDE	LIG_APCC_ABBA_1	0.6471
p.P141L	ACH-000931	Skin Cancer	CCLE	VPVFDE	LIG_APCC_ABBA_1	0.6471
p.P141L	ACH-001024	Skin Cancer	CCLE	VPVFDE	LIG_APCC_ABBA_1	0.6471
p.R155W	TCGA-EO-A22U	UCEC	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.0556
p.R152H	TCGA-IB-7651	PAAD	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.1389
p.E145K	TCGA-IG-A51D	ESCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.7022
p.T150I	TCGA-L5-A8NH	ESCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.1944
p.S139N	TCGA-ZF-AA4W	BLCA	TCGA	VPVFDE	LIG_APCC_ABBA_1	0.3056
p.F155Y	DO5500	BRCA	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.0556
p.V134M	DO219795	LGG	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.1667
p.V145L	DO229026	LICA	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.6765
p.G131V	DO23414	LINC	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.0833
p.R143S	DO45465	LUSC	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.7427
p.F149S	DO219466	SKCM	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.2222
p.R143M	DO229259	THCA	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.8632
p.A148V	DO42023	UCEC	ICGC	VPVFDE	LIG_APCC_ABBA_1	0.25
p.P140L	SW1417	large_intestine	COSMIC	VPVFDE	LIG_APCC_ABBA_1	0.7582
p.C152S	HCC1569	breast	COSMIC	VPVFDE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N465	D-2-hydroxyglutarate dehydrogenase, mitochondrial	LIG_APCC_ABBA_1	140:145	VPVFDE	APC,CDC20,FZR1	0.5648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons