DegronMD - Q8N475(FSTL5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G451W	TCGA-22-4613	LUSC	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.25
p.Q466K	TCGA-75-5146	LUAD	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1389
p.P467L	TCGA-AP-A059	UCEC	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1111
p.V464L	TCGA-AX-A2HC	UCEC	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.V464L	DO41572	UCEC	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1944
p.F454L	TCGA-CA-6718	COAD	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.587
p.F454L	DO7801	COAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.587
p.I465V	TCGA-DD-AA3A	LIHC	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1667
p.N452Y	TCGA-FR-A8YC	SKCM	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.N452Y	DO50301	SKCM	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.E446K	TCGA-JW-A5VL	CESC	TCGA	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1111
p.E445K	DO49976	CESC	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.I452L	DO228538	GACA	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.I455V	DO52192	LIHC	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.7076
p.Y455S	DO50816	LIRI	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.6009
p.Q465K	DO25228	LUAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.1667
p.G460E	DO220891	MELA	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.3056
p.E468K	DO228558	PRAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.S469C	DO46897	RECA	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.P457L	DO41361	UCEC	ICGC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation altering degron motif	0.7582
p.R444I	SIDM01119	Other Solid Cancers	GDSC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.R444I	ACH-000775	Lung Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.R444I	NCI-H727	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.G451R	SIDM00545	Melanoma	GDSC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.25
p.G451R	ACH-000987	Skin Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.25
p.G451R	Mewo	skin	COSMIC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.25
p.N452D	SIDM00296	Small Cell Lung Carcinoma	GDSC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.N452D	ACH-002051	Lung Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.N452D	LU-134-A	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2778
p.R444S	ACH-000937	Leukemia	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0556
p.I468M	ACH-000992	Head and Neck Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.E445D	ACH-001991	Primary	CCLE	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.0833
p.N451D	LU-134-A	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.25
p.G450R	Mewo	skin	COSMIC	FYVFYE	LIG_APCC_ABBA_1	454:459	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FSTL5

UniProt ID: Q8N475

Entrez ID: 56884

Protein name: Follistatin-related protein 5 (Follistatin-like protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FSTL5 in