DegronMD

Uniprot ID: Q8N475

Source protein: Follistatin-related protein 5

Source gene: FSTL5

Class: LIG_APCC_ABBA_1

Location: 454:459

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.908

ASA_SCORE: 47.7833

COIL: 0.2913

CONS_SCORE: 0.6996

DSS_SCORE: 0.0279

HELIX: 0.0192

FCONS_SCORE: 1.4152

RIG_SCORE: 0.9633

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G451W	TCGA-22-4613	LUSC	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.25
p.Q466K	TCGA-75-5146	LUAD	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.1389
p.P467L	TCGA-AP-A059	UCEC	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.1111
p.V464L	TCGA-AX-A2HC	UCEC	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.1944
p.V464L	DO41572	UCEC	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.1944
p.F454L	TCGA-CA-6718	COAD	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.587
p.F454L	DO7801	COAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.587
p.I465V	TCGA-DD-AA3A	LIHC	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.1667
p.N452Y	TCGA-FR-A8YC	SKCM	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.N452Y	DO50301	SKCM	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.E446K	TCGA-JW-A5VL	CESC	TCGA	FYVFYE	LIG_APCC_ABBA_1	0.1111
p.E445K	DO49976	CESC	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.0833
p.I452L	DO228538	GACA	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.I455V	DO52192	LIHC	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.7076
p.Y455S	DO50816	LIRI	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.6009
p.Q465K	DO25228	LUAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.1667
p.G460E	DO220891	MELA	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.3056
p.E468K	DO228558	PRAD	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.0833
p.S469C	DO46897	RECA	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.0556
p.P457L	DO41361	UCEC	ICGC	FYVFYE	LIG_APCC_ABBA_1	0.7582
p.R444I	SIDM01119	Other Solid Cancers	GDSC	FYVFYE	LIG_APCC_ABBA_1	0.0556
p.R444I	ACH-000775	Lung Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.0556
p.R444I	NCI-H727	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	0.0556
p.G451R	SIDM00545	Melanoma	GDSC	FYVFYE	LIG_APCC_ABBA_1	0.25
p.G451R	ACH-000987	Skin Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.25
p.G451R	Mewo	skin	COSMIC	FYVFYE	LIG_APCC_ABBA_1	0.25
p.N452D	SIDM00296	Small Cell Lung Carcinoma	GDSC	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.N452D	ACH-002051	Lung Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.N452D	LU-134-A	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	0.2778
p.R444S	ACH-000937	Leukemia	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.0556
p.I468M	ACH-000992	Head and Neck Cancer	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.0833
p.E445D	ACH-001991	Primary	CCLE	FYVFYE	LIG_APCC_ABBA_1	0.0833
p.N451D	LU-134-A	lung	COSMIC	FYVFYE	LIG_APCC_ABBA_1	0.25
p.G450R	Mewo	skin	COSMIC	FYVFYE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FYVFYE

Degron related mutations and impact score

Drug responses associated with FSTL5 mutations

All proteins holding degron of FYVFYE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N475	Follistatin-related protein 5	LIG_APCC_ABBA_1	454:459	FYVFYE	APC,CDC20,FZR1	0.908	More...