DegronMD - Q8N488(RYBP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S148Y	TCGA-19-5956	GBM	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.712
p.P144H	TCGA-A5-A1OF	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7694
p.S148F	TCGA-AX-A05Z	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7982
p.S148F	TCGA-VQ-A8P2	STAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7982
p.A152T	TCGA-AX-A0J1	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7139
p.K143T	TCGA-EJ-A6RC	PRAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.3056
p.R145Q	TCGA-FI-A2D0	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7329
p.T141I	TCGA-HC-7740	PRAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.25
p.S147Y	DO13863	GBM	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.712
p.T160I	DO220853	MELA	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1111
p.R141K	DO51060	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.25
p.T140I	DO36262	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2222
p.K142T	DO219249	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.2778
p.S147F	DO51761	STAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7982
p.S147F	DO40884	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7982
p.P143H	DO42568	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.3056
p.R144Q	DO43891	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7329
p.A151T	DO41199	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.7139
p.V158I	SIDM00789	Colorectal Carcinoma	GDSC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1667
p.V158I	HCT-15	large intestine	COSMIC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation rewiring degron network	0.1667
p.P136L	SIDM00007	Other Solid Cancers	GDSC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation blocking ubiquitination signal	0.5556
p.P136L	MCC13	skin	COSMIC	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation blocking ubiquitination signal	0.5556
p.G150C	ACH-000834	Bladder Cancer	CCLE	SRPRLKNVD	DEG_APCC_DBOX_1	144:152	Mutation altering degron motif	0.76

Kaplan plot for RYBP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RYBP

UniProt ID: Q8N488

Entrez ID: 23429

Protein name: RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RYBP in