DegronMD

Uniprot ID: Q8N488

Source protein: RING1 and YY1-binding protein

Source gene: RYBP

Class: DEG_APCC_DBOX_1

Location: 144:152

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9879

ASA_SCORE: 88.6667

COIL: 0.6861

CONS_SCORE: 0.6369

DSS_SCORE: 0.6321

HELIX: 0.1661

FCONS_SCORE: 1.143

RIG_SCORE: 0.7285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S148Y	TCGA-19-5956	GBM	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.712
p.P144H	TCGA-A5-A1OF	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.7694
p.S148F	TCGA-AX-A05Z	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.7982
p.S148F	TCGA-VQ-A8P2	STAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.7982
p.A152T	TCGA-AX-A0J1	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.7139
p.K143T	TCGA-EJ-A6RC	PRAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R145Q	TCGA-FI-A2D0	UCEC	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.7329
p.T141I	TCGA-HC-7740	PRAD	TCGA	SRPRLKNVD	DEG_APCC_DBOX_1	0.25
p.S147Y	DO13863	GBM	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.712
p.T160I	DO220853	MELA	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.1111
p.R141K	DO51060	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.25
p.T140I	DO36262	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.2222
p.K142T	DO219249	PRAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.2778
p.S147F	DO51761	STAD	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.7982
p.S147F	DO40884	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.7982
p.P143H	DO42568	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.3056
p.R144Q	DO43891	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.7329
p.A151T	DO41199	UCEC	ICGC	SRPRLKNVD	DEG_APCC_DBOX_1	0.7139
p.V158I	SIDM00789	Colorectal Carcinoma	GDSC	SRPRLKNVD	DEG_APCC_DBOX_1	0.1667
p.V158I	HCT-15	large_intestine	COSMIC	SRPRLKNVD	DEG_APCC_DBOX_1	0.1667
p.P136L	SIDM00007	Other Solid Cancers	GDSC	SRPRLKNVD	DEG_APCC_DBOX_1	0.5556
p.P136L	MCC13	skin	COSMIC	SRPRLKNVD	DEG_APCC_DBOX_1	0.5556
p.G150C	ACH-000834	Bladder Cancer	CCLE	SRPRLKNVD	DEG_APCC_DBOX_1	0.76

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N488	RING1 and YY1-binding protein	DEG_APCC_DBOX_1	144:152	SRPRLKNVD	APC,CDC20,FZR1	0.9879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons